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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALEXANDER'S DISEASE: Alexander's Disease is an extremely rare, progressive, metabolic, neurological disorder that is frequently inherited. It is one of a group of diseases known as the leukodystrophies.

WHAT CHARACTERIZES THIS DISEASE? Alexander's Disease is characterized by loss of the fatty layers that cover nerves (demyelination), and the formation of abnormal bodies (Rosenthal fibers) in supporting cells (astrocytes) of the brain. These Rosenthal fibers most frequently form on the surface of the brain and around the blood vessels within the brain.

WHAT ARE THE SYMPTOMS? The symptoms of Alexander's Disease usually begin during infancy and are associated with mental and physical retardation. Juvenile (occuring later than infancy) and adult-onset Alexander's Disease are recognized forms of this disorder but occur very infrequently.

WHAT ARE SOME OTHER NAMES FOR THIS DISEASE?

• Dysmyelogenic Leukodystrophy
• Dysmyelogenic Leukodystrophy-Megalobare
• Fibrinoid Degeneration of Astrocytes
• Fibrinoid Leukodystrophy
• Hyaline Panneuropathy
• Leukodystrophy with Rosenthal Fibers
• Megalencephaly with Hyaline Inclusion
• Megalencephaly with Hyaline Panneuropathy